Mathematical Oncology Projects

Glioblastoma is a highly aggressive brain tumor that is notoriously difficult to treat, with many therapies proving ineffective. One of the challenges in treating glioblastoma is that Chimeric Antigen Receptor T-Cells (CAR-T) therapies have limited efficacy due to the blood-brain barrier and the immunosuppressive tumor microenvironment. The goal of my project was to investigate how Extracellular Vesicles (EVs) might enhance the effectiveness of CAR-T cells and to develop mathematical models to explore the potential of combining EVs with CAR-T therapy as a novel treatment strategy.